ANALISIS SURVIVAL PENDERITA GAGAL GINJAL DENGAN PENDEKATAN MULTIVARIATE ADAPTIVE REGRESSION SPLINE

Abstract

Survival analysis is a statistical method where the outcome variable that is considered is the time until the occurrence of an event or called an event. Survival analysis in the medical world can be used to test the survival of patients suffering from a disease, one of which is kidney failure. Based on the results of the 2013 Basic Health Research, 0.2% of the total population of Indonesia, namely 499,800 people, experienced kidney failure. Kidney failure is a process of decreasing kidney function that requires renal replacement therapy, in the form of hemodialysis or kidney transplantation. If the survival data involve independent variables that are thought to affect the survival time, then the Cox Proportional Hazard (PH) regression approach can be developed which can be developed for the Multivariate Adaptive Regression Spline (MARS) approach. The MARS approach is a nonparametric regression approach with high-dimensional data, namely data with an independent variable of 3≤𝑝≤20 and a data sample of 50≤N≤1000. This study aims to describe the characteristics of patients with kidney failure, identify the factors that affect the survival time of patients with kidney failure and determine the MARS model. The MARS approach is obtained from a combination of functional basis, maximum interaction, and minimum observation by trial and error. Based on the model that has been formed using the MARS approach, it is found that the most influential variables on the survival time of patients with kidney failure are age, urea levels, and creatine levels.

Key words: Renal failure, hemodialysis, survival analysis, nonparametric, MARS