EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN KAYU MANIS (Cinnamomum burmanni) PADA MENCIT PUTIH JANTAN

Abstract

Cinnamon leaf extract (Cinnamomum burmanni) contains flavonoid compounds that function to stimulate insulin activation so that it can be used for anti-hyperglycemia.The purpose of this study was to determine the effect of giving cinnamon leaf extract (Cinnamomum burmanni) to male white mice induced by dexamethasone and 10% glucose and to determine the effective dose of cinnamon leaf extract (Cinnamomum burmanni) which can reduce blood glucose levels in mice. hyperglycemia. The group was divided into 6 groups, consisting of negative control, positive control, dose variation of 250mg/kg bw, 500mg/kg bw and 750mg/kg bw and the comparison group was Glibenclamide. The inducer used was dexamethasone 5mg/ml and 10% glucose. Induction of dexametason is carried out for 6 days and continued the administration of 10% glucose for 2 days, then given test preparations from days 7, 14 and 21 after the induction of dexamethasone and glucose 10%.  The results showed that the best dose in reducing blood sugar levels in mice was a dose of 750 mg/KgBW with a percentage reduction of 26.33%. Two-way ANOVA statistical analysis test on the percentage of significant antidiabetic (p<0.05). The conclusion of this study is that the ethanolic extract of cinnamon leaves has the effect of activity in lowering blood glucose levels on the 21st day.